Histopathological changes resulting from the effect of nano-graphene oxide on the liver in laboratory rats

The current study included the use of (48) white male laboratory rats, where rats were divided into six groups, with 8 in each group. second group a concentration 30 mg/kg, third 40 fourth 50 and fifth 60 mg/kg nano graphene oxide. sixth is control results statistical analysis showed significant decrease average body weight. On last day experiment when comparing between treated liver weight groups. Central vein, hepatic sinusoidal dilatation, hepatocyte nucleus replication, rupture, nucleolysis As well as thickening nuclei some hepatocytes, infiltration inflammatory cells, hemorrhage, dissolution necrosis hepatocytes. over-study by transmission electron microscope also changes at cellular level, represented rupture cytoplasm, addition to nucleus.